La solidarietĂ arriva via social network
Dalle 11 al Dipartimento di Scienze Economiche e Aziendali (aula K6). Primo appuntamento pubblico a conclusione del progetto di ricerca “Understanding the Emilian Model: A Network Analysis (NA) Approach to investigate industrial relationships”
Uno studio in collaborazione con il Policlinico Umberto I ha esaminato neonati di mamme positive al SARS-CoV-2 al momento del parto. I risultati pubblicati su JAMA Network Open
MIGENERATION-NET. Il network delle politiche giovanili milanesi Iscrizioni entro il 6 novembre. Saranno presenti la vicesindaco Anna Scavuzzo e gli assessori Lorenzo Lipparini e Laura Galimberti
• Otx2 binds to the promoter/enhancer region of Oct4, Sox2, and Nanog in ESCs and EpiSCs • Otx2 binding to the Nanog promoter helps maintain the integrity of ESC compartments • Loss of this Otx2-binding site induces primed-like features in ESCs • Otx2 regulation of Nanog contributes to ICM differentiation of the epiblast Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, including Otx2, recently have been shown to function during the transition from naive to primed pluripotency. Here we uncover a role for Otx2 in the control of the naive pluripotent state. We analyzed Otx2-binding activity in ESCs and EpiSCs and identified Nanog, Oct4, and Sox2 as direct targets. To unravel the Otx2 transcriptional network, we targeted the strongest Otx2-binding site in the Nanog promoter, finding that this site modulates the size of specific ESC-subtype compartments in cultured cells and promotes Nanog expression in vivo, predisposing ICM differentiation to epiblast. Otx2-mediated Nanog regulation thus contributes to the integrity of the ESC state and cell lineage specification in preimplantation development.
An unseen silicon army is gathering information on Earth and its inhabitants. It’s not an alien reconnaissance mission: smart dust is finally hitting the streets, says Anil Ananthaswamy
condoglianze sentite a tutta la famiglia da parte del network LSNN e tutti i suoi autori.
condoglianze sentite da parte del network LSNN e tutti i suoi autori.
