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HOLLYWOOD BIRTHDAY PARTY 23° anno

XXIII years of glam: your key to Hollywood nightlife

Modernising education and training: a vital contribution to prosperity and social cohesion in Europe

This is the second report on progress under the "Education & Training 2010" work programme. Even though national reforms are going in the right direction, the pace of reform must be speeded up. Investment in pre-school education is of paramount importance for preventing school failure and social exclusion, and for laying the foundations for further learning. The report concludes that, unless significantly greater efforts are made in the areas of early school-leaving, completion of upper-secondary education, and key skills, a larger proportion of the next generation will face social exclusion.

Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Resp

Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells.Sabrina Rotolo 1, Simona Ceccarelli 1, Ferdinando Romano 1, Luigi Frati 1,2, Cinzia Marchese 1, Antonio Angeloni 1* 1 Dipartimento di Medicina Sperimentale, Universita` Sapienza di Roma, Roma, Italy, 2 Istituto Neurologico Mediterraneo ‘‘Neuromed, Pozzilli, ItalyAbstract : BackgroundKeratinocyte growth factor receptor (KGFR) is a splice variant of the FGFR2 gene expressed in epithelial cells. Activation of KGFR is a key factor in the regulation of physiological processes in epithelial cells such as proliferation, differentiation and wound healing. Alterations of KGFR signaling have been linked to the pathogenesis of different epithelial tumors. It has been also hypothesized that its specific ligand, KGF, might contribute to the development of resistance to 5-fluorouracil (5-FU) in epithelial cancers and tamoxifen in estrogen-positive breast cancers.Abstract : Methodology/Principal FindingsSmall interfering RNA was transfected into a human keratinocyte cell line (HaCaT), a breast cancer derived cell line (MCF-7) and a keratinocyte primary culture (KCs) to induce selective downregulation of KGFR expression. A strong and highly specific reduction of KGFR expression was observed at both RNA (reduction = 75.7%, P = 0.009) and protein level. KGFR silenced cells showed a reduced responsiveness to KGF treatment as assessed by measuring proliferation rate (14.2% versus 39.0% of the control cells, P

Protection of the EU's Financial Interests: Commission welcomes European Parliament’s call for increased cooperation by Member States

The European Parliament adopted today a report on the protection of the EU’s financial interests. The European Commission welcomes this document as an important support in the fight against fraud affecting the EU budget. The report by rapporteur Francesco Musotto highlights the paramount importance of a constructive cooperation between the Member States and the Commission. It stresses the key responsibility of the Member States for the sound management of Community revenue and expenditure, in particular in the areas of agriculture and structural funds, and including the recovery of unduly spent sums. Finally, the report requests concrete follow-up actions, including measures against certain Member States

Key states still counting

Same-sex marriage bans projected to win

Bush, Kerry Make Final Bid in Key States

Democratic presidential nominee John Kerry holds six month-old Brianna McElory after attending mass at Saint John Vianney Church in Orlando, Florida, November 1, 2004. This is the final day of campaigning before Kerry faces President George W. Bush in the 2004 U.S. presidential election. Photo by Brian Snyder/Reuters

NATIONAL HOUSING SURVEY SHOWS THAT KEY ''GAPS'' POSE A CHALLENGE TO EXPANDING HOMEOWNERSHIP

Most Americans View Homeownership as Best of Both Worlds -- A Safe Investment With a Lot of Potential

QUALCOMM Hosts Inaugural European BREWTM Developers Conference in London

- Key Presenters Include Representatives from Leading International Operators Verizon Wireless and VIVO as well as VP of Wireless Services for Sony Pictures Digital Networks Rio Caraeff and EA Founder Trip Hawkins -

WHO Executive Body reaffirms WHO leadership on key issues for Global Public Health

Unique opportunity for eradication success now rests with key governments

“We Will Finish Polio Before Year’s End,” say Ministers of HealthJoint Press Release WHO/Rotary International/CDC/UNICEF/

Predicting miscarriage

A key protein could help tell when a pregnancy will fail, weeks in advance.

MEDICINE: THE WEIGHT HORMONE CAN REGULATE OUR IMMUNE SYSTEM

A study carried out by the team of Immune Endocrinology of CNR from Naples, published on the Journal of Clinical Investigation, has underlined the key role played by leptine - a hormone regulating body weight - in the aetiology of serious autoimmune diseases such as experimental multiple sclerosis (experimental allergic encephalitis EAE) and autoimmune diabetes.