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THE FANCONI ANAEMIA/BRCA PATHWAY

THE FANCONI ANAEMIA/BRCA PATHWAY

Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability ”€ a common feature of many human cancers.

Redazione Health 22 Jan 2003
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Protection of the EU's Financial Interests: Commission welcomes European Parliament’s call for increased cooperation by Member States

Protection of the EU's Financial Interests: Commission welcomes European Parliament’s call for increased cooperation by Member States

The European Parliament adopted today a report on the protection of the EU’s financial interests. The European Commission welcomes this document as an important support in the fight against fraud affecting the EU budget. The report by rapporteur Francesco Musotto highlights the paramount importance of a constructive cooperation between the Member States and the Commission. It stresses the key responsibility of the Member States for the sound management of Community revenue and expenditure, in particular in the areas of agriculture and structural funds, and including the recovery of unduly spent sums. Finally, the report requests concrete follow-up actions, including measures against certain Member States

Redazione Economy 22 Feb 2008
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