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Protection of the EU's Financial Interests: Commission welcomes European Parliament’s call for increased cooperation by Member States

Protection of the EU's Financial Interests: Commission welcomes European Parliament’s call for increased cooperation by Member States

The European Parliament adopted today a report on the protection of the EU’s financial interests. The European Commission welcomes this document as an important support in the fight against fraud affecting the EU budget. The report by rapporteur Francesco Musotto highlights the paramount importance of a constructive cooperation between the Member States and the Commission. It stresses the key responsibility of the Member States for the sound management of Community revenue and expenditure, in particular in the areas of agriculture and structural funds, and including the recovery of unduly spent sums. Finally, the report requests concrete follow-up actions, including measures against certain Member States

Redazione Economy 22 Feb 2008
298.6K 0
Russia: President signs decree on additional information security measures

Russia: President signs decree on additional information security measures

Russian President Vladimir Putin signed a decree “On additional measures to ensure the information security of the Russian Federation.” The document, published on the official portal of legal information on May 1, states that it should serve to “increase the stability and security of the functioning of the information resources of the Russian Federation.”

LadySilvia® Network Law 04 May 2022
16.7K 0
Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

• Otx2 binds to the promoter/enhancer region of Oct4, Sox2, and Nanog in ESCs and EpiSCs • Otx2 binding to the Nanog promoter helps maintain the integrity of ESC compartments • Loss of this Otx2-binding site induces primed-like features in ESCs • Otx2 regulation of Nanog contributes to ICM differentiation of the epiblast Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, including Otx2, recently have been shown to function during the transition from naive to primed pluripotency. Here we uncover a role for Otx2 in the control of the naive pluripotent state. We analyzed Otx2-binding activity in ESCs and EpiSCs and identified Nanog, Oct4, and Sox2 as direct targets. To unravel the Otx2 transcriptional network, we targeted the strongest Otx2-binding site in the Nanog promoter, finding that this site modulates the size of specific ESC-subtype compartments in cultured cells and promotes Nanog expression in vivo, predisposing ICM differentiation to epiblast. Otx2-mediated Nanog regulation thus contributes to the integrity of the ESC state and cell lineage specification in preimplantation development.

CNR Science 22 Jun 2016
179.2K 0
PlayStation data theft hits 77m gamers

PlayStation data theft hits 77m gamers

Sony has warned users of its PlayStation Network that their personal information, including credit card details, may have been stolen.

Redazione Internet 27 Apr 2011
166.1K 0
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