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State aid: Commission adopts guidance on training aid and aid to disadvantaged and disabled workers

The European Commission has adopted two guidance papers setting out criteria for the in-depth assessment of large amounts of training aid and of aid to disadvantaged and disabled workers. The guidance outlines the kind of information required by the Commission for its assessment and the assessment methodology, which is based on the balancing of the positive and negative effects of the aid. The criteria are in line with the Commission's refined economic approach in state aid analysis, based on the principles set out in the State Aid Action Plan (see IP/05/680 and MEMO/05/195 ). They are part of the Commission's efforts to clarify and simplify state aid rules.

Il Cabaret al Teatro Manzoni di Milano CAVEMAN

Sei al 7° anno di matrimonio? Ti stai per sposare? Vi state lasciando? State per andare a vivere insieme? … Ti conviene vedere Caveman! Continua in Italia il grande successo di CAVEMAN l’uomo delle caverne, il più famoso spettacolo sul rapporto di coppia a livello planetario.

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

• Otx2 binds to the promoter/enhancer region of Oct4, Sox2, and Nanog in ESCs and EpiSCs • Otx2 binding to the Nanog promoter helps maintain the integrity of ESC compartments • Loss of this Otx2-binding site induces primed-like features in ESCs • Otx2 regulation of Nanog contributes to ICM differentiation of the epiblast Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, including Otx2, recently have been shown to function during the transition from naive to primed pluripotency. Here we uncover a role for Otx2 in the control of the naive pluripotent state. We analyzed Otx2-binding activity in ESCs and EpiSCs and identified Nanog, Oct4, and Sox2 as direct targets. To unravel the Otx2 transcriptional network, we targeted the strongest Otx2-binding site in the Nanog promoter, finding that this site modulates the size of specific ESC-subtype compartments in cultured cells and promotes Nanog expression in vivo, predisposing ICM differentiation to epiblast. Otx2-mediated Nanog regulation thus contributes to the integrity of the ESC state and cell lineage specification in preimplantation development.

Strategy against illegal, unreported and unregulated fishing

The Commission presents a comprehensive strategy to combat illegal, unreported and unregulated fishing (IUU) which endangers the economy of the fisheries sector, fish stocks and the marine environment. The measures proposed would restrict access to the European Union (EU) market to those fishery products certified compliant with regulations by the flag State or by the export State in question. It also provides for surveillance of activities at sea, identification of IUU operators, improved implementation of legislation in the fisheries field and better application of sanctions in the event of infringements being committed. The initiative falls within the scope of the Community action plan to eradicate IUU fishing adopted in 2002 and follows on from actions carried out internationally (FAO, RFMO).

Manchester City Nissan Under Fire: Deceptive Practices and Hidden Costs Uncovered by the FTC and the State of Connecticut

Guida pratica all'uso dell'Intelligenza Artificiale Generativa nell'esercizio legale

Rivoluzione Etica nella Pratica Legale: L'Approvazione della Guida sulla Generative Artificial Intelligence dalla State Bar della California

Milano si risveglia: Riaperti i parchi dopo il maltempo, scopri quali sono fruibili

Dopo il lungo periodo di chiusura a causa del maltempo, Milano torna alla normalità e apre alcune delle sue aree verdi e parchi recintati. Grazie all'impegno dei tecnici agronomi e delle autorità locali, diverse aree sono state dichiarate sicure e pronte ad accogliere nuovamente il pubblico. Scopriamo quali sono i parchi riaperti e le misure di sicurezza adottate.

Bitcoin: L'evoluzione del Pagamento Elettronico Peer-to-Peer e i Nuovi Orizzonti dell'Ecosistema Digitale

Ispirato dell'articolo originale di Satoshi Nakamoto Nota introduttiva: Questo articolo esplora le origini del Bitcoin, tenendo conto del fatto che alcune informazioni potrebbero essere state aggiornate nel corso del tempo. Abbiamo selezionato le sezioni chiave dell'articolo originale e le abbiamo adattate al nostro contesto, al fine di fornire una spiegazione chiara e concisa.

Colorado: Revised CPA rules filed with Secretary of State

New York: Bill on data subject rights introduced to State Senate

Employment and Labour on Workers Month Inspection campaign

Workers Month Inspection campaign nets scores of non-compliant employers found to be in contravention of labour laws in Free State

Trump Must Testify in New York Investigation, Judge Rules

Former President Donald Trump must answer questions under oath in New York state’s civil investigation into his business practices, a judge ruled Thursday.